Informatics for Integrating Biology and the Bedside (i2b2) is one of the projects sponsored by the NIH National Centers for Biomedical Computing. The purpose of this project is to provide clinical investigators with the software tools necessary to integrate medical record and clinical research data in the genomics age, a software suite to construct and integrate the modern clinical research chart. Patient medical record data, including diagnoses, medications, laboratory values, and outcome variables, along with the accompanying patient demographics and encounter information can be combined with clinical research data into a single cohesive unit and be queried in a manner that is unprecedented in clinical research. This is achieved by maintaining specific aspects of ontology management, data ownership, and patient privacy while overlaying a generic data architecture. The generic data model and the service oriented architecture of i2b2 lends itself to a natural implementation of a distributed query system, for example the Shared Health Research Information Network (SHRINE) at Harvard. Shawn Murphy and Zak Kohane present.