Created by the Regenstrief Institute in the mid-1990's, the Indiana Network for Patient Care (INPC) is one of the nation’s most comprehensive and longest tenured health information exchanges, containing more than 3.1 billion coded standardized clinical observations, a global patient index containing more than 20 million person entities that represent more than 12 million unique persons, and a physician cohort exceeding 19,000 providers. The system allows physicians working in a variety of clinical settings, with the patient's permission, to view as a single virtual record all previous care at dozens of Indiana hospitals. A centrally managed federated clinical data repository, the INPC supports many other use cases including public health reporting, clinical research, and quality reporting. In this presentation, the INPC framework and supported applications are described. Shaun Grannis presents.