OMOP is a public-private partnership chaired by the FDA and administered by the Foundation for the National Institutes of Health. OMOP conducts methodological research to inform the appropriate use of observational healthcare data including administrative data and electronic health records. OMOP has established a central research laboratory and a distributed data network of over 150 million lives, and has developed a series of standardized analytics to characterize data sources to support the understanding of the effects of medical products. In this discussion the OMOP team presents the OMOP common clinical information model and applications of systematic tools across the data network. The presentation demonstrates how these tools have been applied for many use cases identified as priorities within the ONC Query Health initiative. Patrick Ryan, Marc Overhage and Tom Scarnecchia present.